A New Iodovinyl Derivative of Methyl Pyropheophorbide d Obtained via Takai Olefination Reaction

DOI: 10.6060/mhc224669b

  • Evgeny S. Belyaev ИФХЭ РАН
  • Anastasiya S. Toms
Ключевые слова: Хлорины, хлорофилл а, тетрапиррольные соединения, реакция Такаи, Pd-катализируемые реакции кросс-сочетания.

Аннотация

Modification of chlorin derivatives, which leads to extention of the conjugation chain along the y axis, is the most important direction in the field of natural tetrapyrrole compounds. Our scientific group is interested in the search and development of universal methods which allowing us to introduce substituents of various nature and at the same time, extend the conjugation chain along the y axis of the macrocycle. A new alternative way for functionalization of C32-position of formyl group methyl pyrophrophorbide d by introducing of iodine has been developed. We have proposed an one-step synthesis of methyl 3-(2-iodovinyl)pyropheophorbide d that including Takai reaction between methyl pyropheophorbide d, iodoform and CrCl2. This functionalized derivative can be useful for further synthesis derivatives with π-extending system by Pd-catalysed cross-coupling reaction.

Литература

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Опубликован
2022-12-29
Как цитировать
Belyaev, E., & Toms, A. (2022). A New Iodovinyl Derivative of Methyl Pyropheophorbide d Obtained via Takai Olefination Reaction. Макрогетероциклы/Macroheterocycles, 15(3), 147-152. извлечено от http://mhc-isuct.ru/article/view/4669
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