Стратегия синтеза тетрапиррольных фотосенсибилизаторов для их практического применения в фотодинамической терапии

  • Oskar I. Koifman Институт макрогетероциклических соединений, Ивановский государственный химико-технологический университет
  • Tatyana A. Ageeva
  • Natalia S. Kuzmina
  • . et al

Аннотация

В настоящем обзоре представлен широкий спектр тетрапиррольных фотосенсибилизаторов, применяемых для фотодинамической терапии, антимикробной фотодинамической терапии, фотоинактивации патогенов. Рассмотрены методы синтеза и дизайн новых фотосенсибилизаторов, обладающих большей селективностью накопления в опухолевой ткани и повышенной фотоиндуцированной противоопухолевой активностью. Обсуждаются вопросы исследования свойств новых фотосенсибилизаторов, их фотоактивность, способность генерировать синглетный кислород, и возможности применения таргетной фотодинамической терапии в клинической практике. В обзоре рассмотрены работы по ФДТ отечественных и зарубежных исследователей.

Для цитирования:

Koifman O.I., Ageeva T.A., Kuzmina N.S., Otvagin V.F., Nyuchev A.V., Fedorov A.Yu., Belykh D.V., Lebedeva N.Sh., Yurina E.S., Syrbu S.A., Koifman M.O., Gubarev Y.A., Bunin D.A., Gorbunova Yu.G., Martynov A.G., Tsivadze A.Yu., Dudkin S.V., Lyubimtsev A.V., Maiorova L.A., Kishalova M.V., Petrova M.V., Sheinin V.B., Tyurin V.S., Zamilatskov I.A., Zenkevich E.I., Morshnev P.K., Berezin D.B., Drondel E.A., Kustov A.V., Pogorilyy V.A., Noev A.N., Eshtukova-Shcheglova E.A., Plotnikova E.A., Plyutinskaya A.D., Morozova N.B., Pankratov A.A., Grin M.A., Abramova O.B., Kozlovtseva E.A., Drozhzhina V.V., Filonenko E.V., Kaprin A.D., Ryabova A.V., Pominova D.V., Romanishkin I.D., Makarov V.I., Loschenov V.B., Zhdanova K.A., Ivantsova A.V., Bortnevskaya Yu.S., Bragina N.A., Solovieva A.B., Kuryanova A.S., Timashev P.S. Макрогетероциклы. 2022, 15, 207-302.

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Опубликован
2022-12-31
Как цитировать
Koifman, O., Ageeva, T., Kuzmina, N., & et al, . (2022). Стратегия синтеза тетрапиррольных фотосенсибилизаторов для их практического применения в фотодинамической терапии. Макрогетероциклы, 15(4), 207-302. https://doi.org/10.6060/mhc224870k
Раздел
Макрогетероциклы