Synthesis of Macrolides with Fragments of Diethylene Glycol and Hydrazides of Dicarboxylic Acids from 7-Oxooctanoic Acid
DOI: 10.6060/mhc224242y
Аннотация
Исходя из доступной 7-оксооктановой кислоты разработаны синтезы двух потенциально полезных макролидов с диэтиленгликольным и дигидразидными фрагментами с использованием на ключевых стадиях [2+1]-взаимодействия последней с дитозилатом диэтиленгликоля и [1+1]-конденсации образующегося α,ω-дикетодиэфира с дигидразидами адипиновой и L-(+)-винной кислот. Структура полученных соединений установлена с помощью ИК- и ЯМР-спектроскопии и подтверждена данными хромато-масс-спектрометрии.
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