Стратегия синтеза тетрапиррольных фотосенсибилизаторов для их практического применения в фотодинамической терапии
Аннотация
В настоящем обзоре представлен широкий спектр тетрапиррольных фотосенсибилизаторов, применяемых для фотодинамической терапии, антимикробной фотодинамической терапии, фотоинактивации патогенов. Рассмотрены методы синтеза и дизайн новых фотосенсибилизаторов, обладающих большей селективностью накопления в опухолевой ткани и повышенной фотоиндуцированной противоопухолевой активностью. Обсуждаются вопросы исследования свойств новых фотосенсибилизаторов, их фотоактивность, способность генерировать синглетный кислород, и возможности применения таргетной фотодинамической терапии в клинической практике. В обзоре рассмотрены работы по ФДТ отечественных и зарубежных исследователей.
Для цитирования:
Koifman O.I., Ageeva T.A., Kuzmina N.S., Otvagin V.F., Nyuchev A.V., Fedorov A.Yu., Belykh D.V., Lebedeva N.Sh., Yurina E.S., Syrbu S.A., Koifman M.O., Gubarev Y.A., Bunin D.A., Gorbunova Yu.G., Martynov A.G., Tsivadze A.Yu., Dudkin S.V., Lyubimtsev A.V., Maiorova L.A., Kishalova M.V., Petrova M.V., Sheinin V.B., Tyurin V.S., Zamilatskov I.A., Zenkevich E.I., Morshnev P.K., Berezin D.B., Drondel E.A., Kustov A.V., Pogorilyy V.A., Noev A.N., Eshtukova-Shcheglova E.A., Plotnikova E.A., Plyutinskaya A.D., Morozova N.B., Pankratov A.A., Grin M.A., Abramova O.B., Kozlovtseva E.A., Drozhzhina V.V., Filonenko E.V., Kaprin A.D., Ryabova A.V., Pominova D.V., Romanishkin I.D., Makarov V.I., Loschenov V.B., Zhdanova K.A., Ivantsova A.V., Bortnevskaya Yu.S., Bragina N.A., Solovieva A.B., Kuryanova A.S., Timashev P.S. Макрогетероциклы. 2022, 15, 207-302.
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