Molecular Details of the Interaction of Sorafenib with 2-Hydroxypropyl-β-cyclodextrin

  • Thi Lan Pham Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Van Cuong Bui Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Andrey S. Kuznetsov Gubkin University
  • Xuan Minh Vu Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Thi My Hanh Le Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Tatyana R. Usacheva Ivanovo State University of Chemistry and Technology
  • Jenny Dinh Nhu Zhang Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Minh Bao Ngoc Tran Insitute for Tropical Technology, Vietnam Academy of Science and Technology
  • Irina M. Le-Deygen Lomonosov Moscow State University, Chemical Department
DOI: https://doi.org/10.6060/mhc245799l
Ключевые слова: cyclodextrins, guest - host complex, sorafenib, ATR-FTIR spectroscopy, FTIR microscopy

Аннотация

Present study addresses the molecular aspects of the interaction between the anticancer drug sorafenib and 2-hydroxy-propyl-β-cyclodextrin. Formation of the complex was confirmed by means of powder X-ray diffraction. Infrared microscopy confirmed uniform distribution of sorafenib and 2-hydroxypropyl-β-cyclodextrin. The detailed mechanism of complex formation in an aqueous media was examined using ATR-FTIR spectroscopy. The inclusion of the pyridine ring of sorafenib in the tori of cyclodextrin has been demonstrated, as well as the interaction of the active molecule with the sugar backbone of the carrier. Obtained results provided new details in the mechanisms of complex formation between anticancer drugs and cyclodextrin’s torus.

Литература

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Опубликован
2024-12-24
Как цитировать
Pham, T. L., Bui, V. C., Kuznetsov, A., Vu, X. M., Le, T. M. H., Usacheva, T., Zhang, J. D. N., Tran, M. B. N., & Le-Deygen, I. (2024). Molecular Details of the Interaction of Sorafenib with 2-Hydroxypropyl-β-cyclodextrin. Макрогетероциклы/Macroheterocycles, 17(4), 341-345. https://doi.org/10.6060/mhc245799l
Выпуск
Том 17 № 4 (2024)
Раздел
Циклодекстрины