Antimicrobial Photodynamic Therapy Activity Properties of 2,6-Brominated and -Iodinated BODIPY Core Dyes and their π-Extended 3,5-Distyryl Analogues
Аннотация
The photodynamic antimicrobial chemotherapy (PACT) activity properties of 2,6-dibrominated and -diiodinated meso-methyl phenyl ester BODIPY dyes π-extended with 3,5-p-dibenzyloxystyryl groups at the 3,5-positions were investigated against Gram-(+) Staphylococcus aureus and Gram-(−) Escherichia coli bacteria and Candida albicans fungus using LEDs with output maxima at 660 and 530 nm. The core dyes were found to have significantly higher PACT activities than the π-extended dyes in the context of the Gram-(+) and -(−) bacterial strains, while low PACT activity was also observed against Candida albicans with the 2,6-dibrominated core dye. The results are consistent with the trends reported in a previous study with BODIPY core and 3,5-divinylene dyes and provide further evidence that research related to the PACT activity properties of BODIPYs should focus primarily on halogenated core dyes. The use of a methyl-β-cyclodextrin inclusion complex was found to significantly enhance the aqueous solubility and PACT activity of the 2,6-diiodinated with 3,5-p-dibenzyloxystyryl groups at the 3,5-positions.
Литература
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