Porphyrin-Triazine Hybrid and Its Zinc Complex: Spectroscopy, Electrochemistry and in vitro Cytotoxic Activities against Head and Neck Squamous Cell Carcinoma
Аннотация
Herein, a porphyrin-triazine hybrid 2 and its zinc complex 2-Zn were synthesized and characterized, and the electronic structures were investigated by spectroscopic and electrochemical characterizations. Weak interactions between porphyrin cores and meso-substituted triazine units were confirmed and the influence of solvents on the spectroscopic properties were also discussed. Importantly, these two porphyrins exhibited clearly in vitro cytotoxic activities against head and neck squamous cell carcinoma. Especially, free-base porphyrin-triazine hybrid 2 exhibited much smaller IC50 values by using CAL-27 (0.33±0.06 μg/mL) and CAL-33 (0.021±0.0007 μg/mL), respectively. In addition, their cell photoluminescence properties were also investigated.
Литература
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